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However, unlike ghrelin itself, Ipamorelin does not significantly affect hunger or gastric motility, which makes it an ideal peptide for studies that require GH release without secondary metabolic effects

Percent change (the primary outcome) within and between treatment arms were estimated by modelling the log of the ratio of the month 6 and baseline plaque measures and then exponentiating the relevant model parameter estimates, subtracting one, and multiplying by 100

In the foundational characterization work by Raun and colleagues, Ipamorelin was described as the first GHRP to release growth hormone with a potency and specificity comparable to GHRP-6 but without the accompanying cortisol and prolactin rise

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doi: 10.3390/ijms19041018 12 BrinkmannVReichardUGoosmannCFaulerBUhlemannYWeissDSet al

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